Journal article
Cognition, adaptive skills and epilepsy disability/severity in patients with Lennox–Gastaut syndrome undergoing deep brain stimulation for epilepsy in the ESTEL trial
LJ Dalic, AEL Warren, CB Malpas, W Thevathasan, A Roten, KJ Bulluss, JS Archer
Seizure | Published : 2022
Abstract
Purpose: We previously reported seizure and EEG outcomes of the ESTEL study (Electrical Stimulation of Thalamus for Epilepsy of Lennox–Gastaut phenotype). To assess potential cognitive and behavioral changes during chronic, duty-cycle stimulation of bilateral thalamic centromedian nucleus, we compared standardized cognitive and behavioral measurements, as well as caregiver assessments of disability/severity, before implantation and after 3-months stimulation. Methods: Twenty patients with LGS (17–37 years;13 females) were studied; one participant was not randomized due to DBS device removal, with outcomes of 19 remaining participants reported here. Cognitive and behavioral measurements were ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We thank the participants and their families/caregivers for participating in this research. Our work was supported with funding from the National Health and Medical Research Council (Project Grant #1108881) . LJD is supported by an Australian Government Research Training Program Scholarship. AELW is supported by a post-doctoral fellowship from the Lennox-Gastaut syndrome Foundation and an Early Career Researcher Grant from the University of Melbourne.